Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Improving the function of the kidney graft by verapamil– does it depend on metabolic or haemodynamic effect?

M Nowacki, M Droździk, K Ciechanowski, L Domański, K Safranof, Z Zietek, J Sienko, M Romanowski, T Sulikowski, M Kaminski, K Pabisiak, M Ostrowski

Ann Transplant 2009; 14(1): 58-58 :: ID: 880412


The aim of this study was to evaluate influence of Verapamil on the function of the transplanted kidney three months after transplantation and influence of changing vessel resistance by Verapamil on the functioning transplanted kidney.
Material/Methods: 48 cadaver kidney donors and 96 transplanted patients. The analysed group was 48 kidneys that received injection of 100 μg of Verapamil directly into renal artery 2 minutes before beginning perfusion. The control group was 48 kidneys from the same pair without pre-conditioning with Verapamil.
Results: The level of kidneys' perfusion after adding Verapamil was significantly higher comparing to perfusion of kidneys without adding Verapamil (SD 161 ml/min vs. 111 ml/min). Recipients from the group, that received kidneys after adding Verapamil reached faster the level of 2.0 mg/dL of serum creatinine than recipients from the control group (p<0.005). Level of perfusion did not influence reaching 2.0 mg/dL serum creatinine level in both groups of recipients (p<0.05)
Conclusions: We noticed that Verapamil improves the kidney graft function in the first three months after transplantation. Verapamil reduces kidney's vessel resistance but it does not correlate with improving the function of the kidney after transplantation, however this effect could depend on metabolic effect [blocking calcium channels].

Keywords: Ischemia reperfusion injury, Kidney Transplantation, Organ Perfusion


In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

27 Apr 2022 : Review article  

A Systematic Review of the Literature on Chronic Kidney Disease Following Liver Transplantation

Ann Transplant In Press; DOI: 10.12659/AOT.935170  

Most Viewed Current Articles

31 Dec 1969 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

31 Dec 1969 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

31 Dec 1969 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

31 Dec 1969 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358