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21 May 2009

Correlation between expanded criteria kidney donor parameters and chronic histological lesions

P Domagała, A Perkowska-Ptasińska, A Kwiatkowski, M Wszoła, K Ostrowski, K Cybula, A Chmura

Ann Transplant 2009; 14(1): 58-58 :: ID: 880410

Abstract

Background: Using expanded criteria donor (ECD) organs is one of the
strategies for making more transplants available. In order to evaluate kidneys from expanded criteria donors prior to transplantation donor parameters and histological findings were analysed in this study. Aim: The aim of this study was to investigate the relationship between expanded criteria kidney donor's parameters and histopathological lesions.
Material/Methods: One hundred and seventy two patients received cadaveric
renal transplants between January 1[sup]st[/sup], 2006 and August 31[sup]st[/sup], 2008. Data on donors was collected. In one hundred forty seven cases, renal biopsy specimens obtained perioperatively were available. Cortical interstitial fibrosis, cortical tubular atrophy, arteriosclerosis, total inflammation, arteriolar hyalinization, glomerulosclerosis and thrombotic changes were evaluated.
Results: Average 1-year graft survival was 86.9% for the whole group and the
mean creatinine concentration was 1.58 ml/dl. One case of primary nonfunction was observed (0.6%). More than 25% of transplanted kidneys was harvested from ECD. ECD kidneys presented chronic histological lesions like cortical interstitial fibrosis, cortical tubular atrophy, arteriosclerosis, arteriolar hyalinization and glomerulosclerosis significantly more frequently than standard criteria donor (SCD) kidneys.
Conclusions: Expanded criteria donor kidneys are more likely to contain chronic histological lesions on biopsy.

Keywords: Kidney Transplantation

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358