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Medical Science Monitor Basic Research


eISSN: 2329-0358

Donor and recipient factors affecting the twelve month graft function

M Krajewska, K Kościelska-Kasprzak, D Drulis-Fajdasz, W Weyde, K Madziarska, O Mazanowska, M Kusztal, M Klinger

Ann Transplant 2009; 14(1): 57-57

ID: 880406

Available online:

Published: 2009-05-21

The aim of the study was to evaluate an impact of clinical characteristics potentially important for graft function during the first year.
Material/Methods: The study group encompassed 125 kidney recipients (46 F, 79 M, 46.8±12.3 y.) The observation lasted a minimum of twelve months (30.9±13.0).
Results: The graft function depended on donor and recipient's ages. An influence of gender matching and smoking before transplantation was observed. A negative influence of PRA was noted. An adverse impact of the duration of dialysis on eGFR was found. A signifi cant dependence of DGF and AR was shown. The importance of UA and cholesterol concentration was revealed. Higher CRP concentration was related to higher values of eGFR. In diabetic patients, mean eGFR was lower than in recipients without diabetes. A significant impact of hypertension detected at third month, its intensity, and the number of applied medications were negatively correlated with the eGFR. The presence of proteinuria a month after the procedure was linked to a lower values of GFR. This study indicated a connection between graft function's deterioration and the occurrence of leukopenia and infectious complications.
Conclusions: 1. The novel finding of the study is the positive correlation between CRP level within first three months and eGFR suggesting that higher, but in the normal range CRP is the indicator of more effective IR healing.
2. In addition the multiple factors were revealed associated with recipient
co-morbidities, intensity of the rejection process, and transplanted organ
quality which could be modified by appropriate treatment.

Keywords: Kidney Transplantation