Analysis of machine perfusion parameters of kidneys procured from expanded criteria donors

Background: Using expanded criteria donor's (ECD) organs is one of the
strategies for making more transplants available. Machine perfusion has been proven to offer advantages in kidney storage. Parameters of machine perfusion can be used as a predictors of kidney function after transplantation. Aim: The aim of this study was to analyse the differences in perfusion parameters of kidneys depending on the donor's criteria.
Material/Methods: One hundred and seventy two patients received cadaveric renal transplants between January 1[sup]st[/sup], 2006 and August 31[sup]st[/sup], 2008. Data on donors, recipients and preservation was collected. 88 kidneys were stored by machine perfusion. Parameters of perfusion such as renal flow, resistance, lactate dehydrogenase and lactates measured in the fourth hour of perfusion were analysed.
Results: Average 1-year graft's survival was 86.9% for the whole group and
mean creatinine concentration was 1.58 ml/dl. One case of primary nonfunction was observed (0.6%). More than 25% of transplanted kidneys were harvested from ECD. Kidneys harvested from ECD had significantly lower total renal flow during perfusion (118±38 vs. 161±48; p<0.001), lower flow per gram of kidney's tissue (0.5±0.15 vs. 0.7±0.21; p<0.001) and higher resistance (0.32±0.16 vs. 0.21±0.09;p <0.001) in comparison to kidneys harvested from standard criteria donors (Table).

Keywords: Kidney Transplantation, Organ Perfusion