K Tejchman, L Domański, T Sulikowski, M Kamiński, J Sieńko, M Romanowski, M Ostrowski
Ann Transplant 2009; 14(1): 53-54
Available online: 2009-05-21
Reperfusion of transplanted kidney is connected with many metabolic changes which are the result of the kidney's initial condition and preservation. These alterations are the part of ischemia-reperfusion injury with acid-base balance disorders as one of them. The study's purpose was the analysis of its inï¬‚uence on the kidney function during 24 months after transplantation. The examined group consisted of 86 recipients. Measurements had been made 9 times - 0, 1, 3, 5, 10, 15, 20, 25, 30 minutes after unclamping renal vessels including: blood sample for gas analysis, expiratory pCO[sub]2[/sub], tidal volume and respiratory rate. The evaluation of temporary acid-base balance state was made on the basis of common parameters: pH, pCO[sub]2[/sub], [HCO[sub]3[/sub]-], BE. Examined patients were in general anaesthesia with stable external conditions (O2 saturation, heart rate, blood pressure, temperature). Blood samples were analyzed using Corning 278 and 248 blood gas analyzer; vital parameters were recorded using Ohmeda 5250 RGM and DrÃ¤ger Sulla 909V / Julian apparatus. The analysis has shown increasing metabolic acidosis during reperfusion. Disorders are dependent from HLA-DR matching, donor's gender and have inï¬‚uence on early creatinine concentrations after operation. Analysis showed also inï¬‚uence on a long term kidney function parameters.
Keywords: Ischemia reperfusion injury, Kidney Transplantation