Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Anaemia and erythrocytosis after kidney transplantation and 5-year graft survival

J Pinocy-Mańdok, J Chudek, A Kolonko, A Wiecek

Ann Transplant 2009; 14(1): 51-51 :: ID: 880387


Background: Both anaemia and erythrocytosis frequently occur after kidney
transplantation (KTx). However their infl uence on cardiovascular complications and the risk of kidney graft loss is not well documented. The aim of this study was to analyze the influence of both anaemia and erythrocytosis on kidney graft function and patients outcome in a long-term follow-up after kidney transplantation.
Material/Methods: Two hundred ninety nine consecutive patients with at least 12-month post successful kidney transplantation were enrolled in this study. 90.1% of analysed patients had completed a 5-year follow-up period. Anaemia occurred in 29.5% of patients (in 16.1% Hb <11.0g/dl), while erythrocytosis in 19.1% of patients (including 9.0% with Ht >55%). We have analysed the graft function 12 months after KTx and the impact of anaemia or erythrocytosis on 5-year risk of death and graft loss.
Results: In 58% of anaemic patients low haemoglobin concentration did not
reach normal range in the whole observation time after KTx. The mean eGFR-
MDRD 12 months post KTx was significantly lower in patients with anaemia
(44.9±18.8 ml/min vs. 52.9±17.0 ml/min;p=0.01). Better 12-month graft function was observed in patients with erythrocytosis (59.0±18.4 ml/min). Anaemia but not erythrocytosis was associated with the increased risk of graft loss [RR=3.79 (1.97-7.29); p<0.001]. The risk of death was similar in all subgroups.
Conclusions: Anaemia after KTx is associated with a worse kidney graft function and is a strong predictor of graft loss. Erythrocytosis occurs in patients with excellent kidney graft function; nonetheless it did not increase the risk of graft loss or death when properly treated with phlebotomy.

Keywords: Kidney Transplantation


In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

27 Apr 2022 : Review article  

A Systematic Review of the Literature on Chronic Kidney Disease Following Liver Transplantation

Ann Transplant In Press; DOI: 10.12659/AOT.935170  

Most Viewed Current Articles

31 Dec 1969 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

31 Dec 1969 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

31 Dec 1969 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

31 Dec 1969 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358