Evaluation differents immunosuppressive protocols in patients after kidney transplantation

Prevention and control of renal allograft rejection have been some of the main problems since the first kidney transplant. Common use of selective immunosuppressive agents became an effective and safe way of treatment Nevertheless comparing immunosuppressive protocols containing different
types of drugs is still a pivotal aim of many studies. Here we are presenting the experience from two different centres in Szczecin.The aim of our study was to compare two immunosuppressive protocols: Tac MMF steroids with Cs Aza steroids and their efficacy, incidence of acute rejection, side effects, incidence of IGF, DGF and serum creatinine concentrations after 1 month and 1 year. We have investigated medical records of 1248 patients, treated between the years 1990-2007 in two different centres in Szczecin. 553 patients were selected and divided into two groups - Tac MMF steroids protocol recipients (n=135) and Cs Aza steroids protocol recipients (n=418). We observed higher incidence of IGF with Tac MMF steroids protocol use, and higher incidence of DGF with Cs Aza steroids protocol use. There were no significant differences between immunosuppressive protocols and patients gender in regard to episodes of acute rejection. The incidence of acute rejection was higher in younger patients. Side effects after immunosuppressive treatment were more common in Tac MMF steroids protocol recipients and in younger patients. There were no significant differences between the serum creatinine concentrations after 1 month and 1 year in regard to both of the protocols.

Keywords: Immunosuppression, Kidney Transplantation