Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Islets allotransplantations in Poland – case report of the patient with type I diabetes after kidney transplantation

P Fiedor, M Wszoła, A Berman, A Kwiatkowski, K Pawelec, D Dęborska, M Durlik, L Pączek, A Chmura

Ann Transplant 2009; 14(1): 46-46 :: ID: 880367

Abstract

Backgprund: Diabetes is a growing problem in developed countries. The aim of the study was to asses results of the first Polish islets allotransplantations in patients with type I diabetes and after kidney transplantation.
Case Report: Islets transplantation was performed on the 12[sup]th[/sup] of June 2008.
Patient: 39-years old female with type I diabetes since 1984. Since 2003 on
haemodialysis treatment. In March 2007 the kidney transplantation had been
performed. Before islets transplantation: Fasting c-peptide was 0.06 ng/ml,
stimulated c-peptide was 0.21 ng/ml. HBA1C was 7.2 mg%. Daily insulin intake was 76 U (1.3 U/kg/ per day). Patient kept weight between 55-58 kg (BMI 20.5-21.5 kg/m2) Within last 6 months, before islets infusion, episodes of hypoglycaemia were present 6 times (3 times at night).
Results: HLA matching did not reveal incompatibility, cross-match was negative. After islets allotransplantation patient received antibiotics and anticoagulation prophylaxis. Immunosuppression consisted of: Tacrolimus, CellCept, steroids in low doses and Basiliximab. Function of the transplanted kidneys was stable - creatinine level - 1.0-1.6 mg/dl, clearance of creatinine - 55 ml/kg/min. C-peptide at: 3, 14, 30, 90 and 240 days after islets transplantation was respectively: 1.02; 0.39; 0.79; 0.21; 0.39 ng/ml. Stimulated c-peptide 240 days after islets transplantation was 0.69 ng/ml. Daily insulin intake at 3, 14, 30, 90 and 240 days after islets transplantation was respectively: 48U, 38U, 30U, 50U, 39U. HBA1C at 90 and 240 days after islets transplantation was: 5.9 and 6.0 mg/dl. Due to recent subclinical rejection found in kidney's biopsy, steroids withdrawal was impossible. Qualification for another islets infusion had been stopped.
Conclusions: Islets transplantation is a safe method which allows for better
diabetic control and lower daily insulin intake. In some cases it is possible to
give another islet infusion in order to receive full insulin-independence.

Keywords: case report, clinical outcome

Comments

In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

27 Apr 2022 : Review article  

A Systematic Review of the Literature on Chronic Kidney Disease Following Liver Transplantation

Ann Transplant In Press; DOI: 10.12659/AOT.935170  

Most Viewed Current Articles

31 Dec 1969 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

31 Dec 1969 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

31 Dec 1969 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

31 Dec 1969 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358