Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Serum levels of tromboxane B2 in children after liver transplantation

J Pawłowska, A Wierzbicka, P Socha, I Jankowska, M Teisseyre, J Teisseyre, J Socha

Ann Transplant 2009; 14(1): 44-45 :: ID: 880361


Background: To describe the patomechanism of liver damage in children after liver transplantation, including lipid metabolism and oxidative stress. The aim of the study was to assess serum tromboxane B2 levels, lipid parameters and glutathione levels in children after liver transplantion and in healthy controls.
Material/Methods: We studied 75 children after liver transplantation (mean 11.7±5.17 y) with normal liver function, and 77 healthy controls (mean 13.0± 3,6 y).
Results: There were significant differences between children after liver
transplantation and healthy controls in tromboxane B2 (TXB2) levels (8.0-180.0 vs. 7-38.0 pg/ml); [lower-upper quartile], HDL-C (45-61 vs. 42.5-56.0 mg/dl), apolipoprotein A1 (1.38-1.59 vs. 1.12-1.52 g/l) and glutathione (GSH) (558.3-754.1 vs. 745.6-800.2 μmol/ml). Transplanted children had significantly higher tromboxane B2, lipoprotein HDL-C and apolipoprotein A1 concentrations than control children. Both groups presented with similar levels of T-CH, TG, LDL-C, VLDL-C, GPx, Lp(a) and Apo B.
Conclusions: The significantly increased serum tromboxane B2 concentration in children after liver transplantation may point to ongoing inflammation which is not reflected by abnormal liver tests. The study received financial support of the Polish Ministry of Science PB 1977/P01/2007/32.

Keywords: Liver Transplantation


In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

Most Viewed Current Articles

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

24 Jul 2020 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358