EGFR examined between 6 and 24 months predicts long-term kidney transplant survival in patients with inferior graft function

One-year serum creatinine and other clinical and immunological factors remain uncertain predictors of long-term kidney allograft outcome. The aim of our study was to assess the prognostic significance of eGFR (MDRD) monitoring in patients with suboptimal kidney allograft function. This retrospective analysis looked at the eGFR at 6th month post transplant and every 6 m. thereafter in 323 patients who received kidney transplant between 1995 and 2007; follow-up 7.5 yr (range 1.8 to 12). Based on eGFR at 6 m. patients were divided into 3 groups (Table). We identified patients with significant eGFR improvement as judged by >20% increase between 6 and 24 m. Clinical data was similar across groups. Significant kidney function improvement occurred in 32% pts. They did not experience AGR (72 pts) or had an early episode (31 pts). An excellent graft survival was noticed in patients with eGFR improvement between 6 and 24 m; at the end of follow up 95% patients had grafts functioning.

Keywords: Kidney Transplantation