Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Association of a1936g (rs203462) polymorphism of a-kinase anchoring protein 10 with qt interval prolongation during kidney transplantation

M Zukowski, M Kaczmarczyk, J Biernawska, A Binczak, A Ciechanowicz, R Bohatyrewicz, M Brykczynski

Ann Transplant 2009; 14(1): 33-33 :: ID: 880317

Abstract

Background: The purpose of this study was to investigate whether the polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of occurrence of potentially dangerous arrhythmias during kidney transplant.
Material/Methods: Prospective observational study was performed in the Department of Anaesthesiology and Intensive Care of Pomeranian Medical University in Szczecin. Additional patient monitoring during kidney transplant procedure and in the postoperative period consisted of continuous ECG tracing - digital holter ECG monitor type 300-7 Suprima system (Oxford UK). After manual trace analysis, arrhythmia classification was performed, with interval measurement (including QT corrected QT according to Bazett's formula Qtc = QT/RR1/2), ST segment analysis within all channels and analysis of HRV. Subsequently applying PCR-Restriction Fragment Length Polymorphism method, we investigated A1936G (rs203462) AKAP10 polymorphism in 54 kidney recipients. Results: Analysis of variance (ANOVA) showed that the Qtc interval associated with the variant genotypes (GG+AG) was significantly longer compared to the (AA) genotype in kidney recipients p = 0.04. We did not observe a relationship between the AKAP10 polymorphism and other arrhythmias, clinical or environmental factors.
Conclusions: Our data suggested that the AKAP10 (rs203462) GG+AG variation could be associated with an increased risk of severe arrhythmias during kidney transplantation.

Keywords: Kidney Transplantation

Comments

In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

27 Apr 2022 : Review article  

A Systematic Review of the Literature on Chronic Kidney Disease Following Liver Transplantation

Ann Transplant In Press; DOI: 10.12659/AOT.935170  

Most Viewed Current Articles

31 Dec 1969 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

31 Dec 1969 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

31 Dec 1969 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

31 Dec 1969 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358