Association of a1936g (rs203462) polymorphism of a-kinase anchoring protein 10 with qt interval prolongation during kidney transplantation
M Zukowski, M Kaczmarczyk, J Biernawska, A Binczak, A Ciechanowicz, R Bohatyrewicz, M Brykczynski
Ann Transplant 2009; 14(1): 33-33
Background: The purpose of this study was to investigate whether the polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of occurrence of potentially dangerous arrhythmias during kidney transplant.
Material/Methods: Prospective observational study was performed in the Department of Anaesthesiology and Intensive Care of Pomeranian Medical University in Szczecin. Additional patient monitoring during kidney transplant procedure and in the postoperative period consisted of continuous ECG tracing - digital holter ECG monitor type 300-7 Suprima system (Oxford UK). After manual trace analysis, arrhythmia classification was performed, with interval measurement (including QT corrected QT according to Bazett's formula Qtc = QT/RR1/2), ST segment analysis within all channels and analysis of HRV. Subsequently applying PCR-Restriction Fragment Length Polymorphism method, we investigated A1936G (rs203462) AKAP10 polymorphism in 54 kidney recipients. Results: Analysis of variance (ANOVA) showed that the Qtc interval associated with the variant genotypes (GG+AG) was significantly longer compared to the (AA) genotype in kidney recipients p = 0.04. We did not observe a relationship between the AKAP10 polymorphism and other arrhythmias, clinical or environmental factors.
Conclusions: Our data suggested that the AKAP10 (rs203462) GG+AG variation could be associated with an increased risk of severe arrhythmias during kidney transplantation.
Keywords: Kidney Transplantation