21 May 2009
Impact of tumour characteristic on the outcome of liver transplantation in patients with HCC
K Dudek, O Kornasiewicz, P Remiszewski, K Kobryń, B Ziarkiewicz-Wróblewska, B Górnicka, K Zieniewicz, M KrawczykAnn Transplant 2009; 14(1): 28-28 :: ID: 880299
Abstract
Background: The aim of this study was to identify predictors of survival of 58
patients, with hepatocellular carcinoma (HCC) in cirrhotic liver, treated by liver transplantation (OLTx).
Material/Methods: From January 2001 to December 2008 655 OLTx were
performed in 615 patients. HCC was diagnosed in 58 patients before OLTx and in 66 at histological examination of the explanted livers. 72% of the patients had met Milan criteria at histology.
Results: The median follow-up was 27 months (range, 1-96). We analyzed patient's age and gender, aetiology of liver disease, Child's score at transplantation, episodes of rejection, number and tumour's size, presence of vascular invasion and tumour's differentiation grade. There was no statistically significant difference in survival among patients grouped according to the MELD staging system for HCC. Outcome of the 5-year survival of patients with low differentiated (G3) HCC was significantly worse than patients with moderately differentiated (G2) or well-differentiated (G1) HCC (respectively, G3 50%, G2 81%, and G1 86%, p<0.01). Patients with micro-vascular invasion had a worse 5-yr survival than patients without vascular invasion (42%vs. 80%, p<0.01).
Conclusions: The analysis indicates that histological grade of the tumour and
microscopic vascular invasion are the most predictive factors of overall survival in patients with cirrhosis after liver transplantation for HCC.
Keywords:
In Press
06 May 2022 : Original article
Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...Ann Transplant In Press; DOI: 10.12659/AOT.936293
Most Viewed Current Articles
26 Jan 2022 : Review article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive ModelsDOI :10.12659/AOT.934924
Ann Transplant 2022; 27:e934924
29 Dec 2021 : Original article
Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...DOI :10.12659/AOT.933588
Ann Transplant 2021; 26:e933588
24 Jul 2020 : Review article
Kidney Transplantation in the Times of COVID-19 – A Literature ReviewDOI :10.12659/AOT.925755
Ann Transplant 2020; 25:e925755
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860