21 May 2009
Human papillomavirus as a risk factor for development of cancer in allograft recipients
P Fiedor, Z Wierzbicki, K Pawelec, T Łazowski, A Gardyszewska, P Jurkowski, D Szubińska, K Szymańska, J Wojciula, A Wydrzyńska, M Socha, G Kowalska-Korczak, A Górski, M Durlik, L Pączek, S MajewskiAnn Transplant 2009; 14(1): 24-24 :: ID: 880286
Abstract
Background: Human papillomavirus (HPV) infection is the most common person-to-person transmitted viral infection and has a steadily increasing prevalence. The goal of this study was to evaluate the incidence of oncogenic type 16 HPV infections and development of cancer in patients after organ allotransplantation.
Material/Methods: 650 organ allograft recipients [kidney, kidney-pancreas, liver] transplanted between 1989 and 2003, receiving standard immunosuppressive treatment (CS, CsA, Tac and Aza), were followed for 2-15 years. Activity of specific receptors and mononuclear cells from peripheral blood was assessed and correlated with level of immunosuppression regiments. All patients were examined for the presence of HPV infection (confirmed by PCR).
Results: In 136 patients HPV16 oncogenic infection was found. Out of this number, in 22 patients (16.6%) skin and/or mucosal changes in anogenital area were found. Those patients were surgically treated and the diagnosis of cancer was confirmed by histopathology. The same type 16 of HPV was detected in the oral cavities. All recipients with clinical manifestation of HPV infection including patients with cancer showed abnormality and particularly lower activity of NK, CD4 and CD25 cell receptors. Immunosuppressive treatment was modified in these patients. Recurrence of cancer was observed in three patients 2-5 years after surgical treatment.
Conclusions: Long-term surviving organ allograft recipients with decreased
immune response and HPV infection have a high risk of neoplastic process
development in lower genital tract. Such patients should be carefully monitored and when such complication occurs surgical treatment is necessary with modification of immunosuppressive treatment.
Keywords: viral infections
In Press
06 May 2022 : Original article
Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...Ann Transplant In Press; DOI: 10.12659/AOT.936293
27 Apr 2022 : Review article
A Systematic Review of the Literature on Chronic Kidney Disease Following Liver TransplantationAnn Transplant In Press; DOI: 10.12659/AOT.935170
Most Viewed Current Articles
29 Dec 2021 : Original article
Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...DOI :10.12659/AOT.933588
Ann Transplant 2021; 26:e933588
26 Jan 2022 : Review article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive ModelsDOI :10.12659/AOT.934924
Ann Transplant 2022; 27:e934924
24 Jul 2020 : Review article
Kidney Transplantation in the Times of COVID-19 – A Literature ReviewDOI :10.12659/AOT.925755
Ann Transplant 2020; 25:e925755
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860