Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Arteriolar hyalinization in implantation kidney biopsy as predictor of the graft function

E Ważna, J Pazik, Z Lewandowski, A Perkowska-Ptasińska, S Nazarewski, A Chmura, M Durlik

Ann Transplant 2009; 14(1): 22-22 :: ID: 880279

Abstract

Background: Many factors influence long-term function of transplanted kidney. Increasing number of evidences support the fact that histological assessment of implantation kidney biopsies can predict short- and long-term graft survival. Objective: Kidney function evaluation 2 years after transplantation depends on implantation chronic abnormalities present in donor's biopsy.
Material/Methods: Inclusion criteria: engraftment between 2006-2007 and serum creatinine concentration 1-2 mg/dl at 3 months after transplantation. By chronic abnormalities present in the donors' biopsy were understood arteriolar hyalinization (ah), interstitial fibrosis (ci), sclerotisation of the intimae (cv), tubular atrophy (ct), total inflammation (ti) and sclerotic glomeruli (Banff 2004). Graft function 2 years after engraftment was evaluated by eGFR C&G and serum creatinine concentration. Median observation time was 24.4 (15-32) months. Statistical analysis was performed using GLM Procedure of SAS System.
Results: Baseline transplant function (3 months after transplantation) was  similar in groups with and without chronic abnormalities. In the group with at least one abnormality in comparison to the group without abnormalities in biopsy (24 vs. 14) similar graft function after two years was found. However, graft function was significantly diminished in individuals with graft affected by arteriolar hyalinization (ah) compared to recipients free from ah (16 vs. 36) (mean eGFR values: 51.2±14.8 and 62.0±16.7, respectively - p <0.03, serum creatinine concentrations were 1.76±0.36 and 1.51±0.48 mg/dl, respectively - p<0.09).
Conclusions: The only predictor of graft function at 2 years was ah type abnormalities at implantation. This finding should be considered while choosing immunosuppressive regimen.

Keywords: Kidney Transplantation

Comments

In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

27 Apr 2022 : Review article  

A Systematic Review of the Literature on Chronic Kidney Disease Following Liver Transplantation

Ann Transplant In Press; DOI: 10.12659/AOT.935170  

Most Viewed Current Articles

31 Dec 1969 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

31 Dec 1969 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

31 Dec 1969 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

31 Dec 1969 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358