21 May 2009
Evaluation of cadaveric donor usability for pancreas harvesting
and pancreatic islets transplantation in Poland
K Pawelec, J Czerwiński, A Berman, M Wszoła, P Fiedor
Ann Transplant 2009; 14(1): 21-21 :: ID: 880275
Abstract
Background: Donor shortage is a common problem among all transplant centres. Frequently the acceptance criteria of pancreas for islets isolations are extended to marginal donors. Transplant success rate of islet isolations varies between centres and the ratio is 1/3 to 1/5. Donor status strongly influences islet yield. The clinical Islet Transplantation Programme started in 2008 in Poland, therefore we investigated the potential number of pancreases for islet isolation.
Material/Methods: We analyzed clinical data of 427 effective donors referred to Poltransplant in 2008. Age, ICU stay, treatment with vasoactive drug, hypotension, cardiac arrest, body mass index, glucose and amylase level, past history was analysed. For each variable we allocated points and for each donor total score was calculated (maximal score 75). Applied scoring system was based on literature review and clinical experience.
Results: Of 427 effective donors: 20 (4.7%) became utilised pancreas donors for simultaneous pancreas-kidney procedure. 3 (0.7%) were used for islet isolation (with 1 clinical islet transplantation). Out of remaining 404 donors, 36 had high number of points in the applied score system (over 60) and could be potentially (basing on analysis of clinical risk factors) optimal pancreas donors for islets recovery.
Conclusions: The number of optimal donors that could be allocated for islet isolation should cover the needs of the clinical Islet Transplant Programme. The use of optimal donors should lead to maximize the number of transplantable islet isolations.
In Press
18 Mar 2024 : Original article
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of R...Ann Transplant In Press; DOI: 10.12659/AOT.943282
20 Mar 2024 : Original article
Transplant Nephrectomy: A Comparative Study of Timing and Techniques in a Single InstitutionAnn Transplant In Press; DOI: 10.12659/AOT.942252
28 Mar 2024 : Original article
Association Between FEV₁ Decline Rate and Mortality in Long-Term Follow-Up of a 21-Patient Pilot Clinical T...Ann Transplant In Press; DOI: 10.12659/AOT.942823
02 Apr 2024 : Original article
Liver Transplantation from Brain-Dead Donors with Hepatitis B or C in South Korea: A 2014-2020 Korean Organ...Ann Transplant In Press; DOI: 10.12659/AOT.943588
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860