Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

The Future of Living Kidney Donation

G Danovitch

Ann Transplant 2009; 14(1): 18-18 :: ID: 880259


In the 55 years that have followed the first successful living donor kidney transplant between identical twins, organ transplantation has become one of the medical miracles of our age. The controversies over removing kidneys from healthy donors remain. Within a few years living donor transplantation from first degree relatives became commonplace. In the early 1980's the first transplants from spouses were performed and with advances in immunosuppressive therapy the necessity for close HLA matching was overcome. Living donation from donors who were not biologically related, yet were typically closely emotionally related, became more frequent. Over time the closeness of emotional bond between donor and recipient that was deemed appropriate for donation became more tenuous. By the 1990's transplant from donors with no relationship at all to their recipients were performed in some programs. The identification, evaluation, and protection of these so-called "altruistic", "non-directed", or "good Samaritan" donors and other donors with a limited relationship to the recipient became the subject of intense scrutiny. The last decade has seen a change in the nature of the relationship between living donors and their recipients in the United States. In this respect the United States has taken the lead among developed countries, some of which prohibit biologically unrelated donation even from spouses. Unrelated donation now accounts for approximately 35% of all living donor transplant and in some programs nearly 50% of all living donors have varying degrees of 'unrelatedness'. All this has occurred in a legal environment that prohibits financial gain for the donors and with extensive evidence both of excellent psychosocial outcomes and long-term medical safety. At a time of increasing need for organ donors, both living and deceased, how can we best advance the practice of living donation, protect the health and welfare of living donors, and continue to provide an example to the rest of the world?

Keywords: Kidney Transplant, Organ Transplantation


In Press

06 May 2022 : Original article  

Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...

Ann Transplant In Press; DOI: 10.12659/AOT.936293  

Most Viewed Current Articles

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

24 Jul 2020 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358