Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

Association between pharmacodynamic parameters and clinical events under therapy with EC-MPS in the early phase after kidney transplantation (KTx)

E. Wieland, M. Shipkova, Y. Martius, G. Hasche, C. Klett, R. Bolley, C. Olbricht

Ann Transplant 2008; 13(1): 41-41 :: ID: 880206


Background: Strategies based on monitoring pharmacodynamic effects are increasingly evaluated to optimize immunosuppressive therapy. Pharmacodynamic monitoring is either specific for the particular drug or aimed at a general estimation of the immunosuppression. We have monitored both drug specific and general phramacodynamic parameters and looked on their association with clinical events early after KTx.
Material/Methods: 35 patients receiving basiliximab, EC-MPS (2-720 mg/day), steroids, and tacrolimus (target: 6-8 μg/L) were included. Blood was drawn on days 7(±1) and 21(±2) at C0 h and C2 h. Mononuclear leucocytes were isolated and the following parameters were investigated: IMPDH activity (HPLC-DAD), cell proliferation (BRdU test), CD25[sup]+/[/sup]CD3[sup]+[/sup]- CD71[sup]+[/sup]/CD3[sup]+[/sup]-, and CD26[sup]+[/sup] /CD3[sup]+[/sup] -expression by flow cytometry. Acute rejection, gastrointestinal side effects, leucopenia, and infections were monitored over three month. Results were statistically evaluated by the Mann-Whitney test and odds ratios.
Results: There was no association between events and IMPDH activity apart that patients with diarrhea showed a significantly higher IMPDH activity 2 h after drug intake (p<0.05). Cell proliferation (0h) was significantly reduced in patients with leucopenia (p<0.01). CD71[sup]+[/sup] /CD3[sup]+[/sup]-expression was less inducible in patients with infections  (p<0.05). CD26[sup]+[/sup] /CD3[sup]+[/sup]-expression was highly and significantly associated with rejection particularly on day 7 after KTx (p=0.01; odds-ratio: 16.3). No assotiations were found for the CD25[sup]+[/sup] /CD3[sup]+[/sup] -expression.
Conclusions: A potential of pharmacodynamic monitoring to optimize immunosuppressive combination therapy has been demonstrated. Particularly CD26[sup]+[/sup] /CD3[sup]+[/sup] expression seems to be a promising parameter to predict acute rejection. The lack of association between IMPDH activity and events should be proven in further trials with more

Keywords: catherer, Tacrolimus, leucopenia


In Press

20 Jan 2022 : Original article  

Impact on Waitlist Outcomes from Changes in the Medical Eligibility of Candidates for Simultaneous Liver-Ki...

Ann Transplant In Press; DOI: 10.12659/AOT.934850  

19 Jan 2022 : Original article  

Carbohydrate Metabolism Disorders in Relation to Cardiac Allograft Vasculopathy (CAV) Intensification in He...

Ann Transplant In Press; DOI: 10.12659/AOT.933420  

18 Jan 2022 : Original article  

PLGA+Fe₃O₄+PFP Nanoparticles Drug-Delivery Demonstrates Potential Anti-Tumor Effects on Tumor Cells

Ann Transplant In Press; DOI: 10.12659/AOT.933246  

17 Jan 2022 : Original article  

Impact of Thyroid Incidentaloma on Liver Transplant: A Study of 1010 Recipients at a Single Center

Ann Transplant In Press; DOI: 10.12659/AOT.934988  

Most Viewed Current Articles

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

22 Dec 2021 : Original article  

Comparison of Coronary Artery Calcium Scoring with Dobutamine Stress Echo for Detection of Coronary Artery ...

DOI :10.12659/AOT.934163

Ann Transplant 2021; 26:e934163

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

01 Dec 2021 : Original article  

Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-S...

DOI :10.12659/AOT.934175

Ann Transplant 2021; 26:e934175

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358