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17 June 2008

Non-resectable hepatic tumors in children – role of liver transplantation

Piotr Kaliciński, Hor Ismail, Dorota Broniszczak, Joanna Teisserye, Ludmiła Bacewicz, Małgorzata Markiewicz-Kijewska, Marek Szymczak, Paweł Nachulewicz, Bożenna Dembowska-Bagińska, Przemysław Kluge, Andrzej Kościesza, Adam Kowalski, Marek Stefanowicz, Weronika Kasprzyk, Marek Krawczyk

Ann Transplant 2008; 13(2): 37-41 :: ID: 858105

Abstract

Background: There is a group of children with primary hepatic tumors which can not be resected by conventional partial liver resection. Total hepatectomy followed by liver transplantation may be the only solution in such cases. Authors reviewed own experience with the liver transplantation for unresectable tumors in children and assessed the possible indications and role of transplantation in these patients.
Material and Methods: Liver transplantation was performed in 17 children with unresectable hepatic tumors out of total number of 350 children transplanted. Hepatocarcinoma was present in 8 children, hepatoblastoma in 6 and benign giant hemangioma in 3. There was no other option for the treatment which would lead to the oncological cure of children with malignant tumors. All patients with giant hemangiomas were infants transplanted urgently due to circulatory and then multiorgan failure.
Results: Survival within whole group is 75,5% (13 of 17 pts), 3 children died of malignant tumor recurrence, one of other causes. All 3 children with benign tumors are alive and well. Actual follow-up is from 3 months to 7 years.
Conclusions: Liver transplantation should be considered as option in the treatment of all children with unresectable hepatic tumors. With the careful and individual patient selection significant chances for survival can be achieved in this group of patients which would otherwise not survive with the conventional treatment.

Keywords: primary hepatic tumors , liver resection, Liver Transplantation, children

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358