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Medical Science Monitor Basic Research

AmJCaseRep
MedSciTechnol

eISSN: 2329-0358

Post-Transplantation Histology as Surrogate Markerfor Long-Term Kidney Allograft Outcome

Serdar Yilmaz, Mark Nutley, Eero Taskinen, Timo Paavonen, Pekka Hayry

Ann Transplant 2000; 5(2): 37-43

ID: 497524

Available online:

Published: 2000-06-09


Apart of death with functioning transplant, which is mostly related to cardiovascular complications, poor long-term survivalof renal transplants has been related to chronic rejection. In Dunn's series, the most common cause of kidney graft lossbeyond 2yearswas chronic rejection (36.2%), followed by noncompliance (27.6%), death with a functioning transplant (22%), and acute rejection (8.6%) [1]. Ferguson reported an overall incidence of chronic kidney allograft rejection of 23% over a 3 to 10-year follow-up [2]. Graft failure due to chronic rejection is the leading cause of the estimated yearly 6-12% graft loss after the first year [3]. Chronic rejection does not affect patient survival,but it has a significant effect on the5-yeargraftsurvival[4]...

Keywords: chronic rejection, Pathology, CADI



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