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Medical Science Monitor Basic Research


eISSN: 2329-0358

Disorders of Calcium Metabolism at Various Times after Renal Transplantation

Dmitry Babarykin, Ioara Adamsone, Diana Amerika, Ioese Folkmane, Rafail Rozental

Ann Transplant 1999; 4(1): 46-53

ID: 497443

Available online:

Published: 1999-03-12

Objectives:Increased parathyroid hormone (PTH) ,roductionand related defects of calcium-phosphorusmetabolismcould persist even after successful kidney transplantation. Much more s rious long term consequences after the transplantation are bone defects caused by immunosuppressive drugs. Many authors consider ~ eroid therapy as one of the factors that maintain this process. Our study aimed to investigate calcium-phosphorus and bone pathological feature: during the various post transplantation periods. using non-invasive bone research methods (bone ultrasound structurally-densitornetricanalysi: I.and also to analyse the risk of hyperparathyroidism and steroid therapy in the development of post transplantation osteopathy. Methods: 52 patients after successful kidney transl antation were investigated. All patients were divided in three groups according to the time after transplantation. Ist group-patients in the earli ir post transplantation period. up to I year (n= 12); 2ndgroup-patients in the period from I to 5 years after transplantation (n=25); 3rdgroul -patients in later post transplantation period (more than 5 years after the transplantation, n=15). Results: 8 patients from the 1stgroup (66,7%), I I patients from the 2nd group (72%) and 8 patients from the 3rd group (53,3%) had an increased level of serum creatinine. The level of :orrected serum Ca was increased (p

Keywords: renal transplantation, osteopenia, secondary hyperparathyroidism, steroid therapy