Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

13 March 1998

Microchimerism Following Allogeneic Vascularized Bone Marrow Transplantation - Its Possible Role in Induction of Posttransplantation Tolerance

M Durlik, B Lukomska, H Ziolkowska, A Namyslowski, S Janczewska, E Cybulska, W L Olszewski

Ann Transplant 1998; 3(1): 24-26 :: ID: 497367


We have noticed that bone marrow transplanted in a vascularized limb graft providing a continuous supply of donor BMC may prolong the survival time of skin graft from the same donor. The question arises whether the raised microchimerism playsa role in the prolonged survival of skin allograft. The aim of the study was to follow the development of microchimerism after allogeneic vascularized bone marrow transplantation (VBMTx) concomitantly with the rejection procesess of transplanted skin. The BN rats served as donors and LEW rats as recipients of VBMTx and free skin flap allograft. Hind limb was transplanted followed by afull-thickness skin graft on the dorsum. Cellular microchimerlsm was investigated in recipients ofVBMTx and skin grafts in blood. spleen, mesenteric lymph node and bone marrow with monoclonal antibody OX27 directed against MHC class I polymorthic RTI on BN cells and quantitatively analysed in FACStar. InVBMTx group free skin flap survived 70 daysafter weaning of CsA.lntravenous infusion of BMC in suspension equivalent to that grafted in hind limb did not prolong skin graft survival after cessation of CsA therapy. Donor-derived cells could be detected in VBMTx recipients as long 70 days after wearing of CsA but not in recipients of Lv. suspension BMC grafting.

Keywords: Tolerance, Allograft, Bone Marrow, microchimerism


In Press

11 Jan 2022 : Original article  

Efficacy of Nitric Oxide-Releasing Nanofibers in Reducing Renal Ischemia-Reperfusion Injury in a Rat Model

Ann Transplant In Press; DOI: 10.12659/AOT.934800  

11 Jan 2022 : Original article  

Effects of Substance P for Liver Regeneration in Rat Hepatectomy Models: A Preliminary Experimental Animal ...

Ann Transplant In Press; DOI: 10.12659/AOT.934801  

Most Viewed Current Articles

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

22 Dec 2021 : Original article  

Comparison of Coronary Artery Calcium Scoring with Dobutamine Stress Echo for Detection of Coronary Artery ...

DOI :10.12659/AOT.934163

Ann Transplant 2021; 26:e934163

01 Dec 2021 : Original article  

Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-S...

DOI :10.12659/AOT.934175

Ann Transplant 2021; 26:e934175

23 Nov 2021 : Original article  

The Future Direction of the Organ Donation System After Legislation of the Life-Sustaining Treatment Decisi...

DOI :10.12659/AOT.934345

Ann Transplant 2021; 26:e934345

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358