Alberto Hayek, Gillian M Beattie
Ann Transplant 1997; 2(3): 46-54
Available online: 1997-09-12
Almost 25 years ago following reports of successful shortterm culture of the human fetal pancreas, it was suggested that fetal pancreatic cells could be used as a cell-based insulin delivery system in insulin-dependent diabetes (IDDM) . Several trials using fetal pancreatic explants in transplantation procedures to patients with IDDM were undertaken mostly in Eastern European countries and China (reviewed in ). However, the results of those trials could not be analyzed because the information reported was insufficient to draw valid conclusions. Limited clinical trials in Australia  and the U.S.  indicated that the tissue was antigenic and that it could survive after transplantation under the kidney capsule in immunosuppressed patients who had received a kidney transplant.
Keywords: human fetal pancreatic tissue, proliferation, differentiation, Transplantation