Longitudinal Study of Renal Function in Pediatric Liver Transplant Recipients

Objectives: Study was performed to evaluate prospectively long-term renal function in pediatric liver transplant recipients.
Methods: In 50 children aged 1-18 years, renal function tests (sCr, GFR, ERPF, Cr clearance, renal Doppler ultrasound, ABPM) have been performed before and several times during 36 months follow-up after liver transplantation.
Results: Signifficant reduction of renal filtration function was found in studied children (increase of sCr, decrease of GFR, ERPF, Cr clearance) within 12 months after transplantation, which did not progress further in most children after this time. None of patients progressed to stage 4 or 5 renal failure according to CKD. Schwartz formula was not found reliable in assessing renal function in children after liver transplantation. There was no difference in renal function according to cyclosporine or tacrolimus treatment, however arterial hypertension was more common in cyclosporine treated group.
Conclusions: Although renal damage may be a problem for an individual chuild after liver transplantation, majority of children have stable renal function 36 months after Tx. DTPA GFR should be performed yearly in all children until adulthood not to overlook progression of renal injury.

Keywords: Adolescent, Blood Pressure, Blood Pressure, Child, Child, Child, Preschool, Glomerular Filtration Rate, Hemodynamics, Immunosuppressive Agents - therapeutic use, Infant, Kidney - physiopathology, Kidney Failure, Chronic - prevention & control, Kidney Function Tests, Liver Transplantation, Liver Transplantation, Longitudinal Studies, Prospective Studies, Renal Circulation, Risk Assessment