28 June 2005 : Review article
Innate Immunity Processes in Organ Allografting- Their Contribution to Acute and Chronic Rejection
W L OlszewskiAnn Transplant 2005; 10(2): 5-9 :: ID: 16806
Abstract
Summary: The innate immune processes proceeding in organ allografts and their contribution to acute and chronic rejection have been described. Ischemia/reperfusion phenomenon with damage of the endothelial and parenchymal cells and reaction of granulocytes and
macrophages as well as humoral factors including complement, coagulation factors, free radicals, nitrous oxide have an impact on late function of the transplanted organs. Participation of granulocytes and macrophages in acute allogeneic rejection is another example of the role of the innate system in transplant damage. Recurrent basic disease, diabetes, hyperlipidemia, adverse effects of immunosuppressive drugs in allograft recipients are factors evoking reaction of the innate system. Investigations of the innate immune system have shown an essential role, beside of the adaptive system stimulated by allogeneic mismatch, in organ graft rejection.
Keywords: innate immunity, adaptive immunity, Allotransplantation
In Press
08 Mar 2024 : Original article
Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...Ann Transplant In Press; DOI: 10.12659/AOT.943532
14 Mar 2024 : Original article
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort StudyAnn Transplant In Press; DOI: 10.12659/AOT.943652
14 Mar 2024 : Case report
Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...Ann Transplant In Press; DOI: 10.12659/AOT.942358
15 Mar 2024 : Review article
Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...Ann Transplant In Press; DOI: 10.12659/AOT.941185
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860