The increased number of CD4+CD28- T cells in patients after liver transplantation.
Andrzej Pawlik, Marcin Florczak, Marek Masiuk, Bogusław Machalinski, Marta Syczewska, Zbigniew Szych, Barbara Gawrońska-SzklarzAnn Transplant 2003; 8(2): 55-57 :: ID: 142802
Abstract
It has been observed that the organ manifestations in the patients withautoimmune diseases resulted from vessels damage may be caused by CD4+CD28- T lymphocytes, which expresshigh levels of IFN gamma and posses cytolytic activity. The increased number of these cells in the recipientsof allogenic bone marrow grafts and kidney grafts was also observed. The aim of the study was to evaluatethe amount of CD4+CD28- T lymphocytes in the recipients of allogenic liver grafts. The size of CD4+CD28-T cells compartment has been determined in 20 patients after liver transplantation and 20 healthy subjectsas control group using two-color FACS analysis. The frequency of CD4+CD28- T cells in the liver transplantrecipient was 5.65% and was significantly higher than in control group 1.4% (p < 0.001). The increasedlevel of cytotoxic CD4+CD28- T cells may be involved in vessels damage and gradual loss of graft function.
Keywords:
In Press
06 May 2022 : Original article
Phosphatidylethanol (PEth) for Monitoring Sobriety in Liver Transplant Candidates: Preliminary Results of D...Ann Transplant In Press; DOI: 10.12659/AOT.936293
Most Viewed Current Articles
29 Dec 2021 : Original article
Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...DOI :10.12659/AOT.933588
Ann Transplant 2021; 26:e933588
26 Jan 2022 : Review article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive ModelsDOI :10.12659/AOT.934924
Ann Transplant 2022; 27:e934924
24 Jul 2020 : Review article
Kidney Transplantation in the Times of COVID-19 – A Literature ReviewDOI :10.12659/AOT.925755
Ann Transplant 2020; 25:e925755
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860