W L Olszewski
Ann Transplant 2004; 9(4): 25-25
Available online: 2004-12-15
The transplanted organs are composed of resident cells phenotypically and functionally specific for a given tissue. They also contain migrating cells usually displaying immune properties. The resident cells of an accepted organ their own life. They try to adjust to the recipient environment, absorb nutrients, synthesise specific substances, divide producing progenies, undergo apoptosis and senescence and subsequently degradation. Immunosuppression prevents rejection but further adds to organ cell degradation. Whole cells and cellular debris released from the grafted organ
lodge in recipient lymphoid organs and either are further degraded or stored in the endothelial and dendritic cells. Consecutive steps of processing of that
material are not well known. Some donor cells, mostly belonging to the immune population, survive in the recipient issues.