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Medical Science Monitor Basic Research


eISSN: 2329-0358

Antibodies to HLA Class II Antigens as A Risk Factor for Acute Rejection of The Allogeneic Kidney

A Slavcev, J Lacha, H Sajdlova, S Vitko, S Valhova, I Striz, E Ivaskova

Ann Transplant 2004; 9(3): 44-47

ID: 10217

Available online: 2004-10-29

Published: 2004-10-29

We have investigated the association between the presence of antibodies to HLA class II antigens and the development of acute and chronic rejection after kidney transplantation. Sera from seventy-one patients before, shortly (2 weeks), and in the period between 8 and 22 months after transplantation were analyzed by the standard complement-dependent cytotoxicity (CDC) test, ELISA-LATM, and LAT tests. Absence of antibodies to HLA class II antigens before and shortly after transplantation was associated with a lower incidence of rejection episodes in the first post-transplant year. Donor-specific class II antibodies could not be detected by the ELISA-LAT test and there was no statistically significant difference in serum creatinine levels between the antibody-positive and antibody-negative patient groups two years after transplantation. Our study suggests that anti- HLA class II antibodies represent a risk factor for the development of acute immunological complications during the first year after transplantation.

Keywords: Acute Disease, Adult, Antibodies - blood, Enzyme-Linked Immunosorbent Assay - methods, Graft Rejection - epidemiology, Graft Rejection - etiology, Graft Survival, Histocompatibility Antigens Class II - immunology, Incidence, Incidence, Kidney Transplantation, Predictive Value of Tests, Risk Factors, Risk Factors, Survival Analysis, Transplantation, Homologous