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Medical Science Monitor Basic Research


eISSN: 2329-0358

Plasma Neuropeptide Y Concentration in Kidney Transplant Patients During The Early Posttransplant Period

M Adamczak, F Kokot, J Witkowicz, A Wiecek

Ann Transplant 2004; 9(3): 37-41

ID: 10215

Available online: 2004-10-29

Published: 2004-10-29

Objectives: Haemodialysed patients with chronic renal failure are characterized by elevated plasma neuropeptide Y (NPY) concentration. Successful kidney transplantation is followed by a regression of the uraemic state and normalization of hormonal and metabolic abnormalities. The aim of the present study was to assess the influence of successful kidney transplantation on plasma NPY concentration in patients with chronic renal failure.
Methods: A total of 38 patients with chronic renal failure was examined after successful kidney transplantation. The control group consisted of 33 healthy subjects. In kidney transplant recipients plasma NPY concentration was assessed immediately before kidney transplantation and additionally two times after successful kidney transplantation: 2-4 days after surgical procedure and just before discharge of the patient from the hospital, when the graft excretory function was satisfactory. At the days specified above blood samples for NPY estimation were withdrawn at 8.00 am, 4.00 pm and 12.00 pm.
Results: Plasma NPY concentration in patients before kidney transplantation was significantly (p

Keywords: neuropeptide Y, Kidney Transplantation