Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

29 October 2004

The Role of Calcium and Calcium Channel Blocking Drugs in Damage to The Liver Preserved for Transplantation

M Trocha, A Szelag

Ann Transplant 2004; 9(3): 5-12 :: ID: 10208

Abstract

Calcium plays a crucial role in physiological process in liver cells however in high concentrations these ions can be pathogenic and lead to cell death. Mechanisms responsible for maintaining calcium ion concentration gradient in physiological conditions include transmembrane transport, storage in intracellular organelles and binding to cytoplasmatic proteins. Ischemia, sepsis, anoxia and action of toxins are responsible for uncontrolled influx of calcium and consequently cell damage. Liver damage during its preservation for transplantation is connected with dysfunction of many enzymes, damage of cell membrane and cytoskeleton proteins. During reperfusion Kupffer cells are activated, reactive oxygen species are produced and microcirculation is disordered by calcium – dependent processes. Calcium channel blocking (CCB) drugs exhibit immunomodulatory impact and positive interaction with cyclosporine or tacrolismus. They also have cytoprotective properties during preservation end reperfusion time. They seem to improve liver function, decrease liver cell damage, elevate bile production, decrease lipid peroxydation and free radicals production. But in some experiments CCB do not modify calcium concentration. More research on preservation conditions is needed to increase the probability of a successful liver transplantation.

Keywords: Liver, Preservation, Calcium IonsReperfusion, Calcium Ions, Calcium Channel Blocking Drugs

Add Comment 0 Comments

In Press

08 Mar 2024 : Original article  

Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...

Ann Transplant In Press; DOI: 10.12659/AOT.943532  

14 Mar 2024 : Original article  

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study

Ann Transplant In Press; DOI: 10.12659/AOT.943652  

14 Mar 2024 : Case report  

Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...

Ann Transplant In Press; DOI: 10.12659/AOT.942358  

15 Mar 2024 : Review article  

Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...

Ann Transplant In Press; DOI: 10.12659/AOT.941185  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358