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01 December 2021: Original Paper

Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d Antibody-Mediated Rejection in Kidney Transplant Recipients

Vasishta S. Tatapudi 1*BDEF# , Dessislava Kopchaliiska 2ABC* , Gilberto J. da Gente 2C , Owen F. Buenaventura 2BC , Manpreet Singh 1BC$ , Zoltan Laszik 3BC , Deborah B. Adey 1CDE , Raja Rajalingam 2ADEF*

DOI: 10.12659/AOT.934175

Ann Transplant 2021; 26:e934175

Figure 1 Solid-phase complement-binding characteristics of de novo donor-specific HLA antibodies (dnDSA) in kidney transplant recipientsRelationship between median fluorescence intensity (MFI) of de novo IgG DSA and ability of C1q or C3d-binding capacity. For recipients with multiple dnDSAs, only the immunodominant dnDSAs defined by the highest MFI are plotted. Some of the C3d+ DSA can be also positive for C1q, and vice versa.

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358