14 July 2020: Original Paper
Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats
Shinichi Nakanuma 1ABCDEFG* , Hidehiro Tajima 1AC , Hiroyuki Takamura 1ACG , Seisho Sakai 1A , Ryosuke Gabata 1B , Mitsuyoshi Okazaki 1B , Hiroyuki Shinbashi 1B , Yoshinao Ohbatake 1B , Isamu Makino 1B , Hironori Hayashi 2A , Tomoharu Miyashita 1AC , Sachio Fushida 1A , Tetsuo Ohta 1ACEDOI: 10.12659/AOT.922306
Ann Transplant 2020; 25:e922306
Figure 8 Assessment of single-stranded deoxyribonucleic acid (ss-DNA) expression in the small intestine: The sham group ilea contained no strongly stained ss-DNA-positive cells. The ischemia-reperfusion (IR) group showed some cells that were strongly positive for ss-DNA labeling (black arrows), mainly at the lamina propria, with congestion. Localization of the ss-DNA expression was similar to that of the cleaved caspase-3 expression (A). The IR+milrinone group had fewer of these cells in the small intestines than did the IR group, but the difference was not significant (B).