14 July 2020: Original Paper
Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats
Shinichi Nakanuma 1ABCDEFG* , Hidehiro Tajima 1AC , Hiroyuki Takamura 1ACG , Seisho Sakai 1A , Ryosuke Gabata 1B , Mitsuyoshi Okazaki 1B , Hiroyuki Shinbashi 1B , Yoshinao Ohbatake 1B , Isamu Makino 1B , Hironori Hayashi 2A , Tomoharu Miyashita 1AC , Sachio Fushida 1A , Tetsuo Ohta 1ACEDOI: 10.12659/AOT.922306
Ann Transplant 2020; 25:e922306
Figure 4 Assessment of CD34 expression in the liver parenchyma: CD34 was expressed at the central vein (CV) vascular endothelium (black arrows), but almost no CD34 was expressed around the CV in the sham group. CD34 expression was detected at the sinusoidal endothelium as slightly thickened endothelium along the sinusoid (yellow arrows) in the pericentral zone (zone 3) of the ischemia–reperfusion (IR) group. In the IR+milrinone group, CD34 expression was attenuated and detected as sinusoidal endothelial cells lining the sinusoid (A). The IR group presented significantly elevated zone 3 scores compared with those of the periportal zone (zone 1). The zone 3 score was significantly attenuated in the IR+milrinone group compared with that of the IR group (B). * Significantly different (P<0.05) from zone 1 of the IR group. # Significantly different (P<0.05) from the IR group of the same zone.