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Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation.
Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time... read more

Published: 2018-11-16

Results of Adult Living Donor Liver Transplantation with Sixth-Decade Donors: A Propensity Score Matching Study in a High-Volume Institution

Seok-Hwan Kim, Gil-Chun Park, Shin Hwang, Chul-Soo Ahn, Ki-Hum Kim, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Hwi-Dong Cho, Jae-Hyun Kwon, Yong-Kyu Jung, Su-Min Ha, Sang-Hyun Kang, Sung-Gyu Lee

(Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea)

Ann Transplant 2018; 23:802-807

DOI: 10.12659/AOT.911550

BACKGROUND: We assessed the prognostic impact of donor age on the outcome of adult living donor liver transplantation (LDLT).
MATERIAL AND METHODS: The study population comprised adult donor and recipients of right lobe grafts for LDLT performed from January 2005 to December 2016. There were 35 living donors aged ≥50 years (old-age donor group). As a control group, donors in their 20s (young-age donor group) were selected after one-to-one propensity score matching based on sex, model for end-stage liver disease (MELD) score, and primary diagnosis.
RESULTS: Donor age was 52.5±1.5 years versus 25.4±3.1 years in the old- and young-age donor groups, respectively. Remnant volumes of the 2 groups were 38.9±3.0% versus 38.1±2.9%, respectively (p=0.98). One-month regeneration rate of the remnant liver was 101.1±10.6% versus 104.5±11.8%, respectively (p=0.08), and there was no significant difference in the incidences of donor complications. Mean MELD score was 15 versus 14, respectively (p=0.82). Graft-to-recipient weight ratio was 1.02±0.43 versus 0.91±0.63, respectively (p=0.28). In the recipients, biliary complication occurred in 11.4% versus 8.6%, respectively (p=0.12), and there was no difference in 5-year survival rates of both groups (p=0.15). The 1-week and 1-month regeneration rates of the remnant left liver were 71.6±9.9% and 100.1±10.6% in the old-age group, respectively, whereas those were 80.2±12.1% and 104.5±11.8% in the young-age group, respectively (p=0.08).
CONCLUSIONS: Right lobe grafts from donors aged ≥50 years showed the usual recovery of graft function but rather delayed liver regeneration. Thus, old-aged donors should be selected prudently after consideration of hepatic resection rate, graft size, and hepatic steatosis.

Keywords: Donor Selection, Liver Cirrhosis, Living Donors

Published: 2018-11-13

Recurrence of Hepatitis B Infection in Liver Transplant Patients Receiving Long-Term Hepatitis B Immunogl...

Susanne Beckebaum, Kerstin Herzer, Artur Bauhofer, William Gelson, Paolo De Simone, Robert de Man, Cornelius Engelmann, Beat Müllhaupt, Julien Vionnet, Mauro Salizzoni, Riccardo Volpes, Giorgio Ercolani, Luciano De Carlis, Paolo Angeli, Patrizia Burra, Jean-François Dufour, Massimo Rossi, Umberto Cillo, Ulf Neumann, Lutz Fischer, Gabriele Niemann, Luca Toti, Guiseppe Tisone

Ann Transplant 2018; 23:789-801

DOI: 10.12659/AOT.910176

Published: 2018-11-09

Colonoscopy as Part of Pre-Transplant Work-Up in Successful Kidney Transplant Candidates: Single-Center E...

Jarek Kobiela, Małgorzata Dobrzycka, Roman Danielewicz, Justyna Jończyk, Andrzej J. Łachiński, Zbigniew Śledziński, Alicja Dębska-Ślizień

Ann Transplant 2018; 23:782-788

DOI: 10.12659/AOT.910658