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Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation.
Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time... read more

Published: 2019-10-08

Effects of a Structured Physical Activity Program on Serum Adipokines and Markers of Inflammation and Volume Overload in Kidney Transplant Recipients

Katarzyna Muras-Szwedziak, Anna Masajtis-Zagajewska, Ewa Pawłowicz, Michał Nowicki

(Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Łódź, Łódź, Poland)

Ann Transplant 2019; 24:569-575

DOI: 10.12659/AOT.917047

BACKGROUND: Kidney transplantation (KTx) reverses most abnormalities related to chronic kidney disease (CKD), but sedentary lifestyle persists in most kidney graft recipients. Physical inactivity has been associated with altered adipokine profile and inflammation in CKD. We postulated that increased physical activity achieved through an individually-tailored program can reverse these changes.
MATERIAL AND METHODS: We included 25 clinically stable KTx recipients at least 12 months after transplantation and with eGFR >30 mL/min and 15 age-matched non-dialysis patients with CKD stage 3. Body composition, pattern of daily physical activity, and serum concentrations of leptin, adiponectin, NT-proBNP, and hsCRP were assessed at baseline. All patients in both groups participated in a 12-week supervised exercise program with short cell phone text reminders. All measurements were repeated after 3 months.
RESULTS: Active energy expenditure increased significantly during the 3 months in both the KTx and CKD patients, compared with baseline by 47% (p<0.001) and 20% (p=0.01), respectively. Time spent daily on physical activity was also increased (129±83 vs. 194±142 and 81±56 vs. 124±57 min, respectively, p<0.001). Adipose tissue mass decreased significantly in the KTx group (from 40.8±11 to 38.5±10.3 kg, p=0.01). Serum leptin decreased significantly in both KTx and CKD patients (from 11.5±7.0 to 10.0±5.6, p=0.03 and from 14.1±8.3 to 12.2±6.1 ng/mL, p=0.01, respectively). Serum adiponectin increased only in the KTx group (from 1900±953 to 2015±1133 ng/L, p=0.004). Serum CRP decreased in both groups (from 15.1±5.2 to 14.0±5.6 mg/L, p=0.01 in the KTx group and from 16.5±3.9 to 15.4±4.3 mg/L in the CKD group p=0.05). NTpro-BNP was unchanged during the study.
CONCLUSIONS: Increased physical activity induces beneficial effects on adipokine profile and inflammation but does not seem to affect volume overload in kidney transplant recipients and CKD patients.

Keywords: adipokines, Inflammation, Kidney Transplantation, physical exertion, Renal Insufficiency, Chronic

Published: 2019-10-04

Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Ren...

Zeping Gui, Wencheng Li, Shuang Fei, Miao Guo, Hao Chen, Li Sun, Zhijian Han, Jun Tao, Xiaobin Ju, Haiwei Yang, Ji-Fu Wei, Ruoyun Tan, Min Gu

Ann Transplant 2019; 24:553-568

DOI: 10.12659/AOT.917767

Published: 2019-09-27

Pulmonary Infection Within 100 Days After Transplantation Impaired Platelet Recovery in Patients with Hem...

Roujia Wang, Aijie Huang, Qi Chen, Libing Wang, Lei Gao, Huiying Qiu, Xiong Ni, Weiping Zhang, Jianmin Yang, Jianmin Wang, Xiaoxia Hu

Ann Transplant 2019; 24:541-552

DOI: 10.12659/AOT.917802