H-Index
34
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
call: +1.631.629.4327
Mon-Fri 10 am - 2 pm EST

Logo



eISSN: 2329-0358

Home Page

Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation.
Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time... read more


Published: 2019-07-16

Prognostic Impact of Peritransplant Serum Sodium Concentrations in Liver Transplantation

Plamen Mihaylov, Shunji Nagai, Burcin Ekser, Richard Mangus, Jonathan Fridell, Chandrashekhar Kubal

(Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, USA)

Ann Transplant 2019; 24:418-425

DOI: 10.12659/AOT.914951


BACKGROUND: Serum sodium (Na) is considered to reflect the severity of liver cirrhosis. In the last few years, much effort has been made to integrate this association into prognostic models after liver transplantation. The aim of this study was to investigate the associations between peritransplant Na and neurological complications, as well as short-term survival, after liver transplantation.
MATERIAL AND METHODS: A total of 306 liver transplantations between 2012 and 2015 were evaluated. Pre- and posttransplant sodium concentrations were investigated with regard to 3-month survival and incidence of posttransplant neurological complications, along with other factors present in the operative side of the recipient and donor.
RESULTS: The 3-month survival rate was 94%. Neither hyponatremia (<130 mEq/L) nor hypernatremia (>145 mEq/L) at pretransplantion predicted 3-month survival. A large amount of intraoperative blood transfusion and a large delta Na showed a significant association with poor outcomes at 3 months. On multivariate analysis, the requirement of blood transfusion and warm ischemia time remained independent prognostic factors for 3-month mortality. Hyponatremia and a large delta Na tended to lead to the frequent development of neurological complications. These complications, secondary to rapid Na correction, were concerning and potentially led to a prolonged hospital stay and early mortality.
CONCLUSIONS: Rapid change in the sodium level might be caused by large amounts of blood transfusion products. This leads to a diminished short-term survival, as well as a higher rate of neurological complications.

Keywords: Hyponatremia, Liver Cirrhosis, Liver Transplantation



Related Articles (0)

Coming Soon...

Published: 2019-07-12

Infectious Complications of Induction Therapies in Kidney Transplantation


Adem Bayraktar, Yunus Catma, Arif Akyildiz, Erol Demir, Huseyin Bakkaloglu, Ali Riza Ucar, Ahmet Burak Dirim, Sebahat Usta Akgul, Sonay Temurhan, Ali Fuat Kaan Gok, Yasemin Ozluk, Isin Kilicaslan, Fatma Savran Oguz, Mehmet Sukru Sever, Ali Emin Aydin, Aydin Turkmen

Ann Transplant 2019; 24:412-417

DOI: 10.12659/AOT.915885

Published: 2019-07-09

Patient Knowledge, Attitudes, and Behaviors Associated with Organ Donation


Mehmet Uyar, Lutfi Saltuk Demir, Yasemin Durduran, Reyhan Evci, Zehra Diker Ardıç, Tahir Kemal Şahin

Ann Transplant 2019; 24:407-411

DOI: 10.12659/AOT.916824