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eISSN: 2329-0358

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Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation.
Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time... read more


Published: 2019-08-16

Analysis of Data from the Oxygen Persufflation in Liver Transplantation (OPAL) Study to Determine the Role of Factors Affecting the Hepatic Microcirculation and Early Allograft Dysfunction

Tamas Benkö, Jennifer Belker, Anja Gallinat, Jürgen W. Treckmann, Andreas Paul, Thomas Minor, Dieter P. Hoyer

(Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, University Essen-Duisburg, Essen, Germany)

Ann Transplant 2019; 24:481-488

DOI: 10.12659/AOT.915214


BACKGROUND: Adequate microcirculatory perfusion is essential for the provision of oxygen to the liver following transplantation. Data from the Oxygen Persufflation in Liver Transplantation (OPAL) study (ISRCTN00167887) were analyzed from liver transplants performed at a single center to determine the role of factors affecting the hepatic microcirculation and early allograft dysfunction (EAD).
MATERIAL AND METHODS: Retrospective data from 116 patients from the Oxygen Persufflation as Adjunction in Liver Transplantation (OPAL) study who underwent liver transplantation at a single center were analyzed. Oxygen saturation of hemoglobin (SO₂), relative capillary hemoglobin concentration (rHb), relative tissue blood flow (rBF) using laser Doppler flow measurements, and the Oxygen-to-See (O2C) spectrometry were measured and with post-transplant allograft function were analyzed using univariate and multivariate logistic regression statistics.
RESULTS: Livers donors had a median donor risk index of 1.8. Most liver transplant recipients were men (60.3%), with a median age of 54 years (IQR, 23-68 years). Mean post-transplant 3-month survival was 90.5%. The EAD rate was 22.4%, the median SO₂ was 78% (IQR, 29.5-95.8%), the median rHb was 55.6 AU (IQR, 16.8-74.8 AU), and the median rBF was 110.1 AU (IQR, 35.8-406.8 AU). Multivariate logistic regression analysis showed that tissue SO₂ (p=0.01), body mass index (BMI) of the transplant recipient (p=0.002), serum alanine transaminase (ALT) of the donor (p=0.02), and portal blood flow (p=0.01) were predictive factors for EAD.
CONCLUSIONS: Non-invasive investigations of the liver microcirculation and hemoglobin oxygenation were shown to be predictive factors for EAD following liver transplantation.

Keywords: perfusion imaging, Primary Graft Dysfunction, Risk Assessment




Published: 2019-08-13

Alloresponses of Mixed Lymphocyte Hepatocyte Culture to Immunosuppressive Drugs as an In-Vitro Model of ...


Felix Oldhafer, Eva-Maria Wittauer, Christine S. Falk, Daphne E. DeTemple, Oliver Beetz, Kai Timrott, Moritz Kleine, Florian W.R. Vondran

Ann Transplant 2019; 24:472-480

DOI: 10.12659/AOT.915982

Published: 2019-08-09

Aplastic Anemia Preconditioned with Fludarabine, Cyclophosphamide, and Anti-Thymocyte Globulin


Dan Yang, Jianmin Yang, Xiaoxia Hu, Jie Chen, Lei Gao, Hui Cheng, Gusheng Tang, Yanrong Luo, Weiping Zhang, Jianmin Wang

Ann Transplant 2019; 24:461-471

DOI: 10.12659/AOT.915696