H-Index
34
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
call: +1.631.629.4327
Mon-Fri 10 am - 2 pm EST

Logo



eISSN: 2329-0358

Home Page

Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation.
Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time... read more


Published: 2020-01-24

Different Routes of Proton Pumps Inhibitors Co-Administration have Significant Impact on Mycophenolate Acid (MPA) Serum Levels in Heart Transplant Recipients

Tomasz Urbanowicz, Ewa Straburzyńska-Migaj, Veronica Casadei, Michał Bociański, Marek Jemielity

(Department of Cardiac Surgery and Transplantology, Holy Saint Configuration Hospital University of Medical Sciences, Poznań, Poland)

Ann Transplant 2020; 25:e920225

DOI: 10.12659/AOT.920225


BACKGROUND: Antiproliferative drugs including mycophenolate mofetil (MMF) are widely accepted part of an immunosuppressive therapy following heart transplantation. Proton pump inhibitors (PPIs) are routinely administered after cardiac surgery procedures including transplantation. They may also have impact on mycophenolate acid (MPA) serum levels.
MATERIAL AND METHODS: There were 30 consecutive patients (28 male and 2 female patients) with a mean age of 45±12 years who were enrolled into this study. MPA serum levels were studied; PPIs were intravenously and orally administered.
RESULTS: The mean MPA plasma concentrations were statistically significantly different between parenteral group (2.3±1.4 umg/mL) and oral group (3.1±2.2 umg/mL) (P=0.036) before immunosuppressive drug administration (C-0 time). There was a statistically significant different drug concentration at the second sample time C-30 (30 minutes after drug intake) reaching 4.4±2.8 umg/mL versus 7.9±4.5 umg/mL (P<0.05). There was no statistically significant difference in MPA plasma concentration at the 3rd measurement C-120 (10.7±4,9 umg/mL versus 9.8±5 umg/mL) (P=0.3). There is a statistically significant different MMF serum concentration after oral intake and intravenous infusion at C-30 (2.4±1.4 in group 1 versus 3.3±2.5 in group 2, P<0.036) but not at C-120 time interval (8.9±5.0 versus 9.8±5.3 in group 1 and 2, respectively) (P=0.3).
CONCLUSIONS: Our study was the first study that compared different routes of PPI co-administration on MPA serum levels in a transplant recipient group. Our study revealed that the parenteral route of administration only slowed not decreased MPA pharmacokinetics within 120 minutes following MMF administration.

Keywords: Drug Interactions, Heart Transplantation, Mycophenolic Acid, proton pump inhibitors



Related Articles (0)

Coming Soon...

Published: 2020-01-17

Perioperative Pleural Drainage in Liver Transplantation: A Retrospective Analysis from a High-Volume Live...


Leke Wiering, Felix Sponholz, Andreas Brandl, Tomasz Dziodzio, Maximilian Jara, Richard Dargie, Dennis Eurich, Moritz Schmelzle, Igor M. Sauer, Felix Aigner, Katja Kotsch, Johann Pratschke, Robert Öllinger, Paul Viktor Ritschl

Ann Transplant 2020; 25:e918456

DOI: 10.12659/AOT.918456

Published: 2020-01-14

Applicability of Hypothermic Oxygenate Machine Perfusion Preservation for Split-Liver Transplantation in ...


Daisuke Ishii, Naoto Matsuno, Mikako Gochi, Masahide Otani, Tatsuya Shonaka, Hiroyuki Takahashi, Yuji Nishikawa, Ryo Yoshikawa, Hiromichi Obara, Kazutoshi Miyamoto, Hiroyuki Furukawa

Ann Transplant 2020; 25:e919920

DOI: 10.12659/AOT.919920