Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

19 December 2001

No Evidence for Participation of Non-Adrenergic Non-Cholinergic Subtances in Brain Death-Related Hemodynamic Deterioration of the Feline Potential Heart Donor

GJ. Brandon Bravo Bruinsma, J.J. Bredee, T. J.C. Ruigrok, Van Echteld, J. H.H. Thijssen

Ann Transplant 2001; 6(4): 43-47 :: ID: 497839

Abstract

Objective: The onset of brain death (BD) is associated with a hyperdynamic cardiovascular response caused by the acute sympathetic release of catecholamines. This is followed by progressive hemodynamic deterioration which may preclude heart donation for transplantation. The mechanism of the hemodynamic collapse is not fully understood. Changes in plasma concentrations of non-adrenergic non-cholinergic (NANC) substances. neuropeptide-Y (NP-Y. a vasoconstrictor) and the vasodilators calcitonin gene-related peptide (CGRP) and substance P (SP). were studied in relation to BD-related hemodynamic alterations. Materials and Methods: Cats (6 BD and 6 controls (C» were studied for 6 h. Heart rat~ (HR) and mean arterial pressure (MAP) were monitored. BD was induced at t = 0 min. At t = -5, 15.60, 180 and 360 min. 5 ml arterial blood samples were taken. The plasma was collected and analyzed. The correlations between MAP and NANC levels were calculated. Results: In the BD cats a maximal and significant increase in HR and MAP was observed at t = 2 min. HR returned to basal levels at t = 20 min and remained at that level. However. MAPdeteriorated progressively to 53:t8 mmHg (p 0.00 I vs C) at / =360 min. NP-Yhad increased from 59.7:t2.5 to 110:t20.2 pmoVI (p 0.05 vsC) at t = 15 min, had returned to basal value at t =60 min and remained at that level. CGR Plevels were lower and SP levels did not change vs C but both showed a trend towards higher levels at t =360 min. The correlations between MAP and NP- Y, CGRP and SP appeared to be not significant. Conclusion: No evidence for participation of NANC substances could be demonstrated in brain death-related hemodynamic deterioration of the feline potential heart donor

Keywords: Brain Death, hemodynamic response, Neuropeptides

Add Comment 0 Comments

In Press

08 Mar 2024 : Original article  

Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...

Ann Transplant In Press; DOI: 10.12659/AOT.943532  

14 Mar 2024 : Original article  

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study

Ann Transplant In Press; DOI: 10.12659/AOT.943652  

14 Mar 2024 : Case report  

Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...

Ann Transplant In Press; DOI: 10.12659/AOT.942358  

15 Mar 2024 : Review article  

Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...

Ann Transplant In Press; DOI: 10.12659/AOT.941185  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358