Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

12 March 1999

The Mechanism of Immunological "Enhancement" in Allografts- Distribution of Alloantigen and Alloantiserumin the Recipient

A Namyslowski, W L Olszewski

Ann Transplant 1999; 4(1): 31-38 :: ID: 497439

Abstract

The active or passive "enhancement", by providing the recipient with donor cellular antigens and recipient antiserum against these antigens, has been known for long to prolong the survival time of organ allografts in rodents. Donor-specific blood transfusions seem to prolong the graft survival in animals and man evoking a similar protective mechanism. We investigated the mechanism of the effect of administering the recipient donor cells and antibodies against these cells on prolongation of heart graft survival. AUGust rat (RTIc) cells and WIStar rat (RTlu) antibodies against AUG antigens were labeled with 51 Cr and 1125, respectively. They were administered i.v. into prospective WIS recipients of AUG hearts -II and -10 days before grafting, respectively. The distribution and level of specific radioactivity were measured in the recipient lymphoid organs on days -9, -7 and -I as well as on days + I and +5 after transplantation. The highest levels of radioactivity of both donor cells and host antibodies against these cells were found on they -9 in recipient spleen but not liver, bone marrow and lymph nodes. After heart or skin transplantation. the radioactivity decreased in spleen to increase in liver and bone marrow. No specific accumulation of antibodies against donor antigens was detected in the grafts. These findings point to a role of antigen-antibody complexes located preferentially in the spleen on the downregulation of in vivo response to donor transplantation antigens. Aconcept of "continuous alloantigens elimination" is presented in which a systemic process of shed alloantigen inhibition and degradation in concert with blocking of organ surface antigens is presented.

Keywords: Enhancement, alloantibody, Transplantation

Add Comment 0 Comments

In Press

08 Mar 2024 : Original article  

Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...

Ann Transplant In Press; DOI: 10.12659/AOT.943532  

14 Mar 2024 : Original article  

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study

Ann Transplant In Press; DOI: 10.12659/AOT.943652  

14 Mar 2024 : Case report  

Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...

Ann Transplant In Press; DOI: 10.12659/AOT.942358  

15 Mar 2024 : Review article  

Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...

Ann Transplant In Press; DOI: 10.12659/AOT.941185  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358