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Reversal of hyperglycemia in streptozotocin diabetic mice by xenotransplantation of microencapsulated rat islets

Krystyna Tatarkiewicz, Elzbieta Sitarek, Marek Sabat, Tadeusz Orlowski

Ann Transplant 1997; 2(2): 20-23

ID: 497152

Published: 1997-06-13


Rat pancreatic islets were immunoisolated within alginate capsules with additional polyethyleneimine-protamine-heparin highly biocompatible membrane. Perifusionstudy in vitro demonstrated satisfactory similarities between the insulinrelease profilesof encapsulated and free islets. Concordant xenotransplantation of microencapsulated rat islets significantly prolonged mean time of restored normoglycemia (46:t 15 days) in streptozotocin-diabetic BALB/c mice recipients comparing to uncoated grafts (7:t 2 days).

Keywords: islet, Xenotransplantation, microencapsulation



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