08 December 2006
Dermal Keratinocytes – Protective Mechanical, Biochemical and Immune Functions Related to Grafting
Anna Domaszewska, Waldemar L OlszewskiAnn Transplant 2006; 11(4): 45-52 :: ID: 497046
Abstract
Clinical transplantation of skin remains an unsolved problem. The rejection process is a rapid one and high doses of immunosuppressive drugs are needed to mitigate it, bringing about systemic complications in the recipient. The strong response of skin cells to alloantigens is dictated by their evolutionarily developed innate reaction to the penetrating microorganisms. The details of this mechanism are still unclear. The understanding of immune processes in a transplanted skin requires more knowledge of the physiological functional relationship between the keratinocytes, Langerhans cells, macrophages, fibroblasts and endothelial cells and their receptors and humoral products. Transplanted skin is a site of hostversus- graft and graft-versus-host reaction.
Keywords: Skin, Epidermis, Physiology, Transplantation, Toll-Like Receptors
In Press
08 Mar 2024 : Original article
Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...Ann Transplant In Press; DOI: 10.12659/AOT.943532
14 Mar 2024 : Original article
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort StudyAnn Transplant In Press; DOI: 10.12659/AOT.943652
14 Mar 2024 : Case report
Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...Ann Transplant In Press; DOI: 10.12659/AOT.942358
15 Mar 2024 : Review article
Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...Ann Transplant In Press; DOI: 10.12659/AOT.941185
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860