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Acute Rejection and Delayed Graft Function Risk Factorsof Graft Loss

M Boratynska, T Szepietowski, Z Szewczyk

Ann Transplant 1996; 1(2): 19-22

ID: 496649

Published: 1996-06-21


Acute graft rejection and delayed function are considered to be the major risk factors of short- term aswell aslong-term graft survival. We studied the impact of these factors on graft outcome among 109 renal transplant recipients. All recipients were treated with triple drug protocol. The recipients were divided into two groups: I group included 57 patients with delayed graft function (DGF), II group included 52 patients with immediate graft function (IGF).We studied graft survival, incidence of acute rejection, serum creatinine levels and the causeof graft loss for patients in both groups. Acute rejection episodes occurred in 49% of patients from DGF group and 45% of patients from IGF group. Graft survival in IGF group was better than in DGF group. Actuarial graft survival at I, 2, 3 and 4 years in examined groups was 84%, 82%, 72%, 65% vs. 92%, 86%, 84%,84%, respectively. One-year graftsurvivalin patients with acute rejection from DGF group and IGFgroup was significandy lower than in patients who remained rejection free(69%,74% ' vs. 94%, 96%). We concluded that delayed graft function decreases long-term graft survival, while immediate graft function hasan excellent impact on graft outcome. Acute graft rejection is the strongest risk factor of graft loss.

Keywords: Kidney, immediate graft function, Graft Survival, Delayed Graft Function, Rejection, Transplantation



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