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Welcome to the Annals of Transplantation

Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation.
Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time... read more


Published: 2016-06-23

De Novo Gastric Cancer After Liver Transplantation

Chung-Sik Gong, Moon-Won Yoo, Beom-Su Kim, Shin Hwang, Ki-Hun Kim, Jeong-Hwan Yook, Byung-Sik Kim, Sung-Gyu Lee

(Division of Gastrointestinal Surgery, Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, South Korea)

Ann Transplant 2016; 21:386-391

DOI: 10.12659/AOT.897595


BACKGROUND: In South Korea, which has a high incidence of gastric cancer, the most common de novo malignancy associated with liver transplantation is gastric cancer. This study sought to identify clinicopathologic characteristics in gastric cancer patients after liver transplantation, and to help manage these cases.
MATERIAL AND METHODS: We investigated gastric cancer patients after liver transplantation at Asan Medical Center. We analyzed sex, age, cause of liver transplantation, initiating immunosuppressant, pre-transplantation gastric fibroscopy findings, time interval between transplantation and gastric cancer occurrence, follow-up period, existence of gastric cancer screening, Helicobacter pylori infection, family cancer history, gastric cancer treatment, cancer location, size of tumor, macroscopic gross type, WHO histologic type, Lauren’s classification, TNM stage, and survival.
RESULTS: Of 2968 adult liver transplantation patients at our hospital, 19 were diagnosed with gastric cancer. The mean age at the time of gastric cancer diagnosis was 60.2±6.8 (46–71) years and mean time interval between liver transplantation and diagnosis of gastric cancer was 56.0±30.7 (3.20–113) months. Endoscopic submucosal dissection was done for 10 patients, 4 of whom underwent surgical resection. Surgical resection as an initial treatment was done in 8 patients. One patient received chemotherapy first. The standard incidence ratio of gastric cancer in these patients was 1036 per 100 000 persons (95% CI, 623.7–1,619) in men and 318.9 per 100 000 (95% CI, 4.170–1,774) in wome... read more

Keywords: Early Detection of Cancer, Incidence, Liver Transplantation, Stomach Neoplasms



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