WELCOME TO Annals of Transplantation
Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time to first decision is around 3-4 weeks. Time to publication of accepted manuscripts continues to be shortened, with the Editorial team committed to a goal of 3 months from acceptance to publication.
Expert reseachers and clinicians from around the world contribute original Articles, Review Papers, Case Reports and Special Reports in every pertinent specialty, providing a lot of arguments for discussion of exciting developments and controversies in the field.
Current Volume 19, 2014
Hydroxyectoine ameliorates preservation injury in deceased after cardiac death donors in experimental liver grafts
Pramod Kadaba Srinivasan, Ngwi Fet, Christian Bleilevens, Mamdouh Afify, Benedict Doorschodt, Shintaro Yagi, Gerhild van Echten-Deckert, René Hany Tolba
Ann Transplant 2014;19:165-173
Due to the drastic shortage of organ donors, clinicians are increasingly considering the use of deceased after cardiac death donors (DCD). Compatible solutes like Ectoine and Hydroxyectoine are produced by extremophilic bacteria as a cell protectant to survive in harsh environments. We hypothesized that the addition of Hydroxyectoine to Histidine-Tryptophan-Ketoglutarate solution (HTK) could ameliorate cold ischemic preservation injury of DCD livers.
Material and Methods: Rat livers were harvested from male Wistar rats weighing 250–300 g. Three experimental groups (n=5 per group) were studied: (1) Controls: cold static storage in HTK for 24 h, (2) DCD: 30-min warm ischemia time and 24-h cold static storage in HTK, and (3) DCD+Hydroxyectoine: like DCD, but with 24-h cold static storage in...
Keywords: , cold ischemia, Organ Preservation, Ischemia-Reperfusion Injury, HTK , Hydroxyectoine