Annals of Transplantation



WELCOME TO Annals of Transplantation

Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation.... read more

Current Volume 19, 2014

Published: 2014-04-14

Hydroxyectoine ameliorates preservation injury in deceased after cardiac death donors in experimental liver grafts

Pramod Kadaba Srinivasan, Ngwi Fet, Christian Bleilevens, Mamdouh Afify, Benedict Doorschodt, Shintaro Yagi, Gerhild van Echten-Deckert, René Hany Tolba

Ann Transplant 2014;19:165-173

DOI: 10.12659/AOT.889958


Background: Due to the drastic shortage of organ donors, clinicians are increasingly considering the use of deceased after cardiac death donors (DCD). Compatible solutes like Ectoine and Hydroxyectoine are produced by extremophilic bacteria as a cell protectant to survive in harsh environments. We hypothesized that the addition of Hydroxyectoine to Histidine-Tryptophan-Ketoglutarate solution (HTK) could ameliorate cold ischemic preservation injury of DCD livers.
Material and Methods: Rat livers were harvested from male Wistar rats weighing 250–300 g. Three experimental groups (n=5 per group) were studied: (1) Controls: cold static storage in HTK for 24 h, (2) DCD: 30-min warm ischemia time and 24-h cold static storage in HTK, and (3) DCD+Hydroxyectoine: like DCD, but with 24-h cold static storage in...

Keywords: , cold ischemia, Organ Preservation, Ischemia-Reperfusion Injury, HTK , Hydroxyectoine



 

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